FANCA (Fanconi anemia group A protein): FANCA is a gene that encodes a protein critical for the Fanconi anemia (FA) DNA repair pathway, which helps maintain genomic stability. FANCA is involved in activating the FA core complex to recognize and repair DNA interstrand crosslinks (ICLs), toxic lesions that can block DNA replication and transcription. By coordinating the assembly and recruitment of the FA core complex to damaged DNA, FANCA supports proper DNA repair and prevents genome instability.