APOH

APOH (Apolipoprotein H): APOH, also known as beta-2-glycoprotein I, is a multifunctional plasma protein crucial for maintaining lipid metabolism and hemostasis. It serves as a key component of the antiphospholipid antibody syndrome (APS), playing a regulatory role in the coagulation cascade and preventing thrombosis. APOH also interacts with various molecules including lipoproteins, phospholipids, and coagulation factors, contributing to the modulation of immune responses and the clearance of apoptotic cells. Beyond its role in hemostasis, APOH exhibits anti-inflammatory properties, participating in the regulation of endothelial function and vascular health. Dysregulation of APOH has been implicated in various disorders, including thrombotic diseases, autoimmune disorders, and cardiovascular conditions. Understanding the intricate functions of APOH offers insights into its potential as a diagnostic marker and therapeutic target for diseases involving aberrations in lipid metabolism, coagulation, and immune regulation.