Anti-Deamidated Gliadin Antibodies (IgA & IgG)

Anti-deamidated gliadin antibodies (anti-DGP) are immune proteins produced in response to deamidated fragments of gliadin, a component of gluten. These antibodies, especially when both IgA and IgG subtypes are measured, provide high sensitivity and specificity for detecting celiac disease. Elevated levels indicate an immune response to gluten, often before intestinal damage becomes apparent. Testing for anti-DGP is particularly useful in individuals with suspected celiac disease, including those who have been on a gluten-free diet for a short time. Measuring both IgA and IgG allows for better detection across different immune profiles.

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Description

Who should consider testing for anti-DGP antibodies?

People with symptoms such as chronic diarrhea, abdominal pain, weight loss, fatigue, or skin rashes who suspect gluten sensitivity or celiac disease may benefit from this test. It is also useful in individuals with a family history of celiac disease.

Can anti-DGP antibodies be present even if I don’t have symptoms?

Yes, in some cases, individuals with celiac disease may have no noticeable symptoms but still show elevated anti-DGP levels, indicating silent or latent celiac disease.

Is it possible to get a false result?

Yes, although rare, false positives or negatives can occur, especially if the individual has already been on a strict gluten-free diet for a prolonged period, which may reduce antibody levels.

What is the difference between IgA and IgG in this test?

IgA antibodies are typically more specific for intestinal damage in celiac disease, while IgG antibodies are helpful for detecting immune responses in individuals with IgA deficiency or during early stages of immune activation. Testing both increases diagnostic accuracy.

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Content
Who should consider testing for anti-DGP antibodies?
Can anti-DGP antibodies be present even if I don’t have symptoms?
Is it possible to get a false result?
What is the difference between IgA and IgG in this test?
Who should consider testing for anti-DGP antibodies?
Can anti-DGP antibodies be present even if I don’t have symptoms?
Is it possible to get a false result?
What is the difference between IgA and IgG in this test?
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