25-hydroxy Vitamin D3
25-hydroxy Vitamin D3 (25(OH)D3) is the primary circulating form of vitamin D in the human body and the most accurate marker for assessing vitamin D status. It is synthesized in the skin upon exposure to UVB radiation from sunlight and can also be obtained from dietary sources such as fatty fish, egg yolks, and fortified foods. Once produced or ingested, vitamin D3 is converted in the liver to 25(OH)D3, which is the major storage form of vitamin D. This form is essential for maintaining calcium and phosphate balance, supporting bone health, and modulating immune, endocrine, and neuromuscular functions.
Description
Because it reflects both endogenous production from sunlight and intake from food or supplements, 25(OH)D3 gives a comprehensive view of the body’s vitamin D levels.
Low levels may be associated with bone demineralization, increased risk of fractures, muscle weakness, fatigue, and impaired immune response.
Yes, Vitamin D3 is generally more effective than D2 at raising and maintaining overall vitamin D levels due to its longer half-life and higher binding affinity in the body.
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